Peripheral artery disease, also referred to as PAD, in the lower extremities can cause a lot of discomfort. Pain or cramping most likely occurs during periods of activity, even if you are doing something as simple as walking. For some individuals, this pain can occur even during periods of rest. Other symptoms of peripheral artery disease in the lower extremities might include discoloration of the skin or ulcers. While pain and discomfort generally tends to go away after a few minutes of rest, PAD should be properly diagnosed so that effective treatment may begin to prevent worsening of the situation.